Acute Myocardial Injury: A Perspective on Lethal Reperfusion Injury
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چکیده
منابع مشابه
Acute Myocardial Injury: A Perspective on Lethal Reperfusion Injury
Acute myocardial infarction contributes significantly to mortality in patients with coronary artery disease. Timely reperfusion of an infarct-related artery within a reasonable time-frame after acute coronary occlusion continues to be the most effective intervention in patients to reduce morbidity and mortality. However, restoration of blood flow to reversibly injured cardiocytes (and other car...
متن کاملAcute myocardial infarction and myocardial ischemia-reperfusion injury: a comparison.
Myocardial infarction (MI) denotes the death of cardiac myocytes due to extended ischemia. Myocardial reperfusion is the restoration of coronary blood flow after a period of coronary occlusion. Reperfusion has the potential to salvage ischemic myocardium but paradoxically can cause injury, a phenomenon called as 'reperfusion injury' (IR). Standard histologic, immunohistochemical and Elisa techn...
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A selective history of the pathophysiological, structural, and metabolic changes found during an episode of severe myocardial ischemia in the canine heart is presented. The changes that cause ischemic injury to become irreversible are discussed in detail because these changes are the target of any successful therapy designed to prevent ischemic cell death. Of these, the disruption of the sarcol...
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BACKGROUND Experimental evidence suggests that cyclosporine, which inhibits the opening of mitochondrial permeability-transition pores, attenuates lethal myocardial injury that occurs at the time of reperfusion. In this pilot trial, we sought to determine whether the administration of cyclosporine at the time of percutaneous coronary intervention (PCI) would limit the size of the infarct during...
متن کاملMyocardial Reperfusion Injury
Around the world, and especially in the Western Society, cardiovascular diseases remain one of the leading causes of death.(1) Within the broad range of cardiovas-cular diseases, the proportional burden of ischemic heart disease is especially high within the Middle East, North America, Australia, and the majority of Europe.(2) In the Netherlands, cardiovascular diseases have been the leading ca...
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ژورنال
عنوان ژورنال: Cardiovascular Pharmacology: Open Access
سال: 2017
ISSN: 2329-6607
DOI: 10.4172/2329-6607.1000216